Log‐ratio analysis of microbiome data with many zeroes is library size dependent
نویسندگان
چکیده
منابع مشابه
Effects of library size variance, sparsity, and compositionality on the analysis of microbiome data
Background: Data from 16S amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeroes. Also, since researchers sample a small fraction of the ecosystem, the observed sequences are relative abundances and therefore the data is compositional. Here we evaluate method...
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Measurements of the magnitude or duration of physical phenomenon have the property that they are positive and continuous, except for the possibility of exact zeroes when the phenomenon does not occur. Such data cannot be transformed to normality by power transformations or any other means, and special treatment of the zero observations is usually required. The approach of this paper is to model...
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ژورنال
عنوان ژورنال: Molecular Ecology Resources
سال: 2021
ISSN: 1755-098X,1755-0998
DOI: 10.1111/1755-0998.13391